Targeting the Colorectal Cancer Stem Cell

N Engl J Med. 2017 Aug 31;377(9):888-890. doi: 10.1056/NEJMcibr1706541.
No abstract available

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Cell Dedifferentiation
  • Cetuximab / pharmacology
  • Cetuximab / therapeutic use
  • Colon / cytology*
  • Colorectal Neoplasms / drug therapy
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / pathology*
  • Disease Models, Animal
  • Gene Knock-In Techniques*
  • Humans
  • Mice
  • Molecular Targeted Therapy
  • Neoplastic Stem Cells / drug effects
  • Neoplastic Stem Cells / physiology*
  • Receptors, G-Protein-Coupled / genetics*
  • Receptors, G-Protein-Coupled / metabolism

Substances

  • Antineoplastic Agents
  • LGR5 protein, human
  • Lgr5 protein, mouse
  • Receptors, G-Protein-Coupled
  • Cetuximab