Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer

Nat Genet. 2017 Aug 30;49(9):1294-1295. doi: 10.1038/ng.3944.

Abstract

ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus.

Publication types

  • News

MeSH terms

  • Chromatin / metabolism*
  • Chromatin Assembly and Disassembly / genetics
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Molecular Targeted Therapy
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / therapy
  • Serine Endopeptidases / physiology
  • Transcriptional Regulator ERG / physiology

Substances

  • Chromatin
  • ERG protein, human
  • Transcriptional Regulator ERG
  • Serine Endopeptidases
  • TMPRSS2 protein, human