The role of poly ADP-ribosylation in the first wave of DNA damage response

Nucleic Acids Res. 2017 Aug 21;45(14):8129-8141. doi: 10.1093/nar/gkx565.


Poly ADP-ribose polymerases (PARPs) catalyze massive protein poly ADP-ribosylation (PARylation) within seconds after the induction of DNA single- or double-strand breaks. PARylation occurs at or near the sites of DNA damage and promotes the recruitment of DNA repair factors via their poly ADP-ribose (PAR) binding domains. Several novel PAR-binding domains have been recently identified. Here, we summarize these and other recent findings suggesting that PARylation may be the critical event that mediates the first wave of the DNA damage response. We also discuss the potential for functional crosstalk with other DNA damage-induced post-translational modifications.

MeSH terms

  • Binding Sites / genetics
  • DNA / genetics*
  • DNA / metabolism
  • DNA Breaks, Double-Stranded
  • DNA Breaks, Single-Stranded
  • DNA Damage*
  • DNA Repair*
  • Humans
  • Models, Biological
  • Phosphorylation
  • Poly Adenosine Diphosphate Ribose / metabolism*
  • Poly(ADP-ribose) Polymerases / metabolism
  • Protein Binding
  • Protein Processing, Post-Translational
  • Ubiquitination


  • Poly Adenosine Diphosphate Ribose
  • DNA
  • Poly(ADP-ribose) Polymerases