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Observational Study
. 2017 Aug 30;17(1):433.
doi: 10.1186/s12906-017-1933-7.

A Combination of Coenzyme Q10, Feverfew and Magnesium for Migraine Prophylaxis: A Prospective Observational Study

Free PMC article
Observational Study

A Combination of Coenzyme Q10, Feverfew and Magnesium for Migraine Prophylaxis: A Prospective Observational Study

Angèle Guilbot et al. BMC Complement Altern Med. .
Free PMC article


Background: Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig®, PiLeJe) was investigated in an observational study.

Methods: Adult patients suffering from migraine according to the criteria of the International Headache Society were enrolled by general practitioners (≥2 migraine attacks during previous month; exclusion of chronic migraine and medication overuse) and after a one-month baseline phase, supplemented with one tablet of 100 mg feverfew, 100 mg coenzyme Q10 and 112.5 mg magnesium per day for 3 months.

Results: Supplementation significantly reduced the number of days with migraine headache during third month of supplementation compared to baseline phase (1.3 days ±1.5 versus 4.9 days ±2.6, p < 0.0001; n = 68 intention to treat; primary criterion). The decrease was progressive over the period of supplementation and significant from first month (1st month: -2.5 days ±3.1, p < 0.0001; 2nd month: -3 days ±2.8, p < 0.0001). The proportion of patients with a reduction of at least 50% in the number of days with migraine headache was 75% (51/68) after 3 months, with a progressive increase over the period of supplementation (63.2% [43/68] after 1 month and 70.6% [48/68] after 2 months). The proportion of patients with anxiety and depressive symptoms (Hospital Anxiety and Depression Scale) decreased between baseline phase and third month of supplementation from 61.9% (39/63 patients with information available) to 35% (21/60) for depression and from 52.4% (33/63) to 30% (18/60) for anxiety. An improvement of quality of life (Qualité de Vie et Migraine questionnaire) was also observed. The combination was well tolerated.

Conclusions: Results suggest that the proprietary supplement containing feverfew, coenzyme Q10 and magnesium assessed could be beneficial and safe for the prevention of migraine in adult patients and merits further study.

Trial registration: NCT02901756 , retrospectively registered on August 24, 2016.

Keywords: Coenzyme Q10; Feverfew; Magnesium; Migraine.

Conflict of interest statement

Ethics approval and consent to participate

The study was approved by the French Advisory Committee on Information Processing in Material Research in the Field of Health and the French National Commission on Informatics and Liberty. The study was performed in accordance with the ethical standards laid down in the Declaration of Helsinki and the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines. All patients gave their informed written consent prior to study participation.

Consent for publication

Not applicable.

Competing interests

AG, MB and SAA are respectively, Manager of the scientific department, Research project manager and Clinical project manager at PiLeJe. CL received fees from PiLeJe for advice on the study design and his contribution in the writing of this manuscript.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


Fig. 1
Fig. 1
Disposition of patients and data sets

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