Clinical implications of neoepitope landscapes for adult and pediatric cancers

Genome Med. 2017 Aug 31;9(1):77. doi: 10.1186/s13073-017-0470-9.


Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutational burden. However, a new report publishing the first comprehensive analysis of the pediatric neoepitope landscape suggests that immunotherapies could also hold promise for pediatric cancers.See related research article 10.1186/s13073-017-0468-3.

Keywords: Exome sequencing; Immunotherapy; Neoepitope; Personalized cancer vaccine; RNA sequencing; Whole-genome sequencing.

Publication types

  • Review
  • Comment

MeSH terms

  • Adult
  • Child
  • DNA Mutational Analysis
  • Exome*
  • Genome, Human
  • Genomics
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Immunotherapy
  • Mutation
  • Neoplasms*
  • Sequence Analysis, DNA