Enhancing brown fat with NFIA

Nat Cell Biol. 2017 Aug 31;19(9):1006-1007. doi: 10.1038/ncb3591.


Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.

MeSH terms

  • Adipose Tissue, Brown*
  • Fatty Acids
  • Humans
  • NFI Transcription Factors*
  • Obesity


  • Fatty Acids
  • NFI Transcription Factors