Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: immunohistological assessment correlates with gene amplification

Lancet. 1987 Jul 11;2(8550):69-72. doi: 10.1016/s0140-6736(87)92736-x.


Amplification of the human protooncogene c-erbB-2 was found in 12 of 36 human breast tumours and was associated with increased levels of expression of the c-erbB-2 protein, measured both by immunohistological staining and by western blotting. The use of immunohistological staining to detect the level of expression of the c-erbB-2 protein in human breast adenocarcinomas may be of value in predicting tumour behaviour.

MeSH terms

  • Adenocarcinoma / analysis*
  • Adenocarcinoma / genetics
  • Breast Neoplasms / analysis*
  • Breast Neoplasms / genetics
  • Female
  • Gene Amplification*
  • Humans
  • Prognosis
  • Proto-Oncogene Proteins / analysis*


  • Proto-Oncogene Proteins