Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia

J Clin Immunol. 2017 Oct;37(7):727-731. doi: 10.1007/s10875-017-0437-z. Epub 2017 Aug 31.


ᅟ: Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases.

Purpose: We aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis.

Methods: 16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis.

Results: Clinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin.

Conclusion: In conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases.

Keywords: Bruton’s disease; Helicobacter bilis; agammaglobulinemia; cholangitis.

Publication types

  • Case Reports

MeSH terms

  • Agammaglobulinemia / drug therapy
  • Agammaglobulinemia / microbiology*
  • Agammaglobulinemia / pathology
  • Anti-Bacterial Agents / therapeutic use
  • Cholangitis / drug therapy
  • Cholangitis / microbiology*
  • Cholangitis / pathology
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / genetics
  • Genetic Diseases, X-Linked / drug therapy
  • Genetic Diseases, X-Linked / microbiology*
  • Genetic Diseases, X-Linked / pathology
  • Helicobacter / genetics*
  • Helicobacter Infections / drug therapy
  • Helicobacter Infections / microbiology*
  • Helicobacter Infections / pathology
  • Humans
  • Liver / pathology
  • Male
  • Young Adult


  • Anti-Bacterial Agents
  • DNA, Bacterial
  • DNA, Ribosomal

Supplementary concepts

  • Bruton type agammaglobulinemia