Pregbalin induced recurrent syncopal attacks with prolong QT interval

Ann Noninvasive Electrocardiol. 2018 Jul;23(4):e12489. doi: 10.1111/anec.12489. Epub 2017 Aug 30.


Long QT syndrome may lead to fatal dysrhythmia. Prolongation of QT interval due to pregabalin has been shown in rats and no data is available in humans. We report a 80-year-old female patient using pregabalin. She was presented to emergency room with syncope attacks. Her admission electrocardiography demonstrated prolonged QT interval. After excluding the possible causes of the long QT syndrome, we attributed prolonged QT interval to pregabalin therapy. After discontinuation of pregabalin QT interval returned to normal range and patient experienced no further syncope attacks. It is first time for documentation of prolonged QT due to pregabalin in humans.

Keywords: long QT syndrome; pregabalin; syncope.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Analgesics / adverse effects*
  • Electrocardiography / methods*
  • Female
  • Humans
  • Long QT Syndrome / chemically induced*
  • Long QT Syndrome / diagnosis
  • Long QT Syndrome / physiopathology
  • Pregabalin / adverse effects*
  • Recurrence
  • Syncope / chemically induced*
  • Syncope / diagnosis
  • Syncope / physiopathology


  • Analgesics
  • Pregabalin