Fat-soluble micronutrients and metabolic syndrome

Curr Opin Clin Nutr Metab Care. 2017 Nov;20(6):492-497. doi: 10.1097/MCO.0000000000000412.

Abstract

Purpose of review: Metabolic syndrome (MetS) is associated with increased risk of obesity, type 2 diabetes mellitus and cardiovascular diseases. MetS prevalence has been associated with diet inadequacy. Conversely, the cumulative incidence of MetS has been inversely associated with a Mediterranean-style diet that includes many different health-beneficial nutrients. Adherence to a Mediterranean-style diet could reduce or at least stabilize metabolic risk factors.

Recent findings: Low serum level of fat-soluble micronutrients, such as carotenoids, vitamin (vit) A, D and E, has been linked to MetS. Fat-soluble micronutrients could contribute to prevent MetS thanks to their antioxidant and anti-inflammatory properties (vit E, carotenoids) or to their central role as hormone regulators (vit D) and/or lipid metabolism and glucose homeostasis sensors (vit D and E).

Summary: This review summarizes recent epidemiological studies linking fat-soluble micronutrients to MetS and highlights new evidence on their mechanisms of actions.

Publication types

  • Review

MeSH terms

  • Carotenoids / administration & dosage
  • Carotenoids / blood
  • Diet, Mediterranean
  • Humans
  • Incidence
  • Inflammation / blood
  • Inflammation / epidemiology*
  • Inflammation / prevention & control*
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / epidemiology*
  • Metabolic Syndrome / prevention & control*
  • Micronutrients / administration & dosage*
  • Micronutrients / blood
  • Patient Compliance
  • Prevalence
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Vitamin A / administration & dosage
  • Vitamin A / blood
  • Vitamin D / administration & dosage
  • Vitamin D / blood
  • Vitamin E / administration & dosage
  • Vitamin E / blood

Substances

  • Micronutrients
  • Vitamin A
  • Vitamin D
  • Vitamin E
  • Carotenoids