Physiological/pathological ramifications of transcription factors in the unfolded protein response

Genes Dev. 2017 Jul 15;31(14):1417-1438. doi: 10.1101/gad.297374.117.


Numerous environmental, physiological, and pathological insults disrupt protein-folding homeostasis in the endoplasmic reticulum (ER), referred to as ER stress. Eukaryotic cells evolved a set of intracellular signaling pathways, collectively termed the unfolded protein response (UPR), to maintain a productive ER protein-folding environment through reprogramming gene transcription and mRNA translation. The UPR is largely dependent on transcription factors (TFs) that modulate expression of genes involved in many physiological and pathological conditions, including development, metabolism, inflammation, neurodegenerative diseases, and cancer. Here we summarize the current knowledge about these mechanisms, their impact on physiological/pathological processes, and potential therapeutic applications.

Keywords: ER stress; transcription factors; unfolded protein response.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Disease / genetics
  • Endoplasmic Reticulum Stress
  • Humans
  • Protein Biosynthesis
  • Transcription Factors / antagonists & inhibitors
  • Transcription Factors / metabolism*
  • Transcriptional Activation
  • Unfolded Protein Response / genetics*


  • Transcription Factors