Metformin: A Review of Its Potential Indications

Drug Des Devel Ther. 2017 Aug 22;11:2421-2429. doi: 10.2147/DDDT.S141675. eCollection 2017.


Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years, in addition to glucose lowering, several studies have presented evidence suggesting some potential role for metformin, such as antitumor effect, antiaging effect, cardiovascular protective effect, neuroprotective effect or an optional treatment for polycystic ovary syndrome. This paper will critically review the role of metformin to provide reference for doctors and researchers.

Keywords: PCOS; antiaging effect; antitumor effect; cardiovascular protective effect; metformin; neuroprotective effect.

Publication types

  • Review

MeSH terms

  • Aging / drug effects
  • Antineoplastic Agents / pharmacology
  • Blood Glucose / drug effects
  • Cardiotonic Agents / pharmacology
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Female
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use*
  • Metformin / pharmacology
  • Metformin / therapeutic use*
  • Polycystic Ovary Syndrome / drug therapy


  • Antineoplastic Agents
  • Blood Glucose
  • Cardiotonic Agents
  • Hypoglycemic Agents
  • Metformin