Selective reduction of carboxylic acids to aldehydes with hydrosilane via photoredox catalysis

Chem Commun (Camb). 2017 Sep 12;53(73):10228-10231. doi: 10.1039/c7cc05570f.

Abstract

The direct reduction of carboxylic acids to aldehydes with hydrosilane was achieved through visible light photoredox catalysis. The combination of both single electron transfer and hydrogen atom transfer steps offers a novel and convenient approach to selective reduction of carboxylic acids to aldehydes. The method also features mild conditions, high yields, broad substrate scope, and good functional group tolerance, such as alkyne, ester, ketone, amide and amine groups.

MeSH terms

  • Aldehydes / chemical synthesis*
  • Aldehydes / chemistry
  • Carboxylic Acids / chemistry*
  • Catalysis
  • Molecular Structure
  • Oxidation-Reduction
  • Photochemical Processes
  • Silanes / chemistry*

Substances

  • Aldehydes
  • Carboxylic Acids
  • Silanes