Neuroleptic malignant syndrome: review and analysis of 115 cases

Biol Psychiatry. 1987 Aug;22(8):1004-20. doi: 10.1016/0006-3223(87)90010-2.


Neuroleptic malignant syndrome is a potentially fatal consequence of neuroleptic use that has recently gained wide attention. In this article the authors critically review the previous literature and analyze all case reports in the English-language literature (115 cases) for 43 variables. The results are discussed in light of prior literature, and recommendations are made for future research.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Child
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Mental Disorders / drug therapy*
  • Middle Aged
  • Neuroleptic Malignant Syndrome / diagnosis*
  • Neuroleptic Malignant Syndrome / drug therapy
  • Prognosis


  • Antipsychotic Agents