[Chemical constituents of Chinese red ginseng]
- PMID: 28861969
- DOI: 10.4268/cjcmm20160214
[Chemical constituents of Chinese red ginseng]
Abstract
The chemical constituents of the Chinese red ginseng were systematically investigated by using various column chromatographic methods including D-101 macroporous adsorptive resins and open silica gel column chromatographies as well as high-performance liquid chromatography.Their chemical structures were identified by physico-chemical properties and spectral analyses.Fifty-two compounds were isolated from Chinese red ginseng decoction and identified as 20(S)-ginsenoside Rh₁ (1), 20(R)-ginsenoside Rh₁ (2), ginsenoside Rg₆ (3), 20(22) E-ginsenoside F₄ (4), ginsenoside Rk₃ (5), 20(22) E-ginsenoside Rh₄ (6), ginsenoside Rg₁ (7), 20(S)-ginsenoside Rf-1a(8), 20(S)-ginsenoside Rf(9), 20(R)-ginsenoside Rf(10),20(S)-notoginsenoside R₂ (11),20(R)-notoginsenoside R₂ (12), 20(S)-ginsenoside Rg₂ (13), 20(R)-ginsenoside Rg₂ (14), ginsenoside Rs₂ (15),ginsenoside Rs₁ (16),ginsenoside Rd(17),notoginsenoside R₁ (18),ginsenoside Re₂ (19), ginsenoside Re(20), 20-gluco-ginsenoside Rf(21),quinquenoside-R₁ (22),ginsenoside Ro methyl ester(23),ginsenoside Ro(24),ginsenoside Rb₁ (25),ginsenoside Rc(26),ginsenoside Rb₂ (27),ginsenoside Ra₂ (28),ginsenoside Ra₃ (29),ginsenoside Rb₃ (30),20(22)Z-ginsenoside Rh₄ (31),chikusetsusaponin IVa butyl ester(32), 20(22)Z-ginsenoside Rs₄ (33),ginsenoside Rs₅ (34),20(22)E-ginsenoside Rs₄ (35),zingibroside R1-6'-butyl ester(36), chikusetsusaponin IVa methyl ester(37),20(S)-ginsenoside Rs₃ (38),20(R)-ginsenoside Rs₃ (39),zingibroside R1-6'-methyl ester(40),ginsenoside Rz₁ (41),ginsenoside Rk₁ (42),ginsenoside Rg₅ (43),23-O-methylginsenoside-Rg₁ ₁ (44),12β,25-dihydroxydammar-20(22)E-ene-3-O-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranoside(45), 20(22)Z-ginsenoside F₄ (46),3β,12β-dihydroxydammar-20(22)E,24-diene-6-O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranoside(47), 20(S)-ginsenoside Rg₃ (48),20(R)-ginsenoside Rg₃ (49),20(22)E-ginsenoside Rg₉ (50),ginsenoside-Ro-6'-butyl ester(51), and polyacetyleneginsenoside Ro(52). Compounds 8, 12, 31-33, 36, 37, 44, 45, 47 and 51 were isolated from the P. ginseng, and compounds 19, 23 and 46 were isolated from Chinese red ginseng for the first time.
Keywords: Chinese red ginseng; Panax ginseng; chemical constituents; ginsenoside.
Copyright© by the Chinese Pharmaceutical Association.
Conflict of interest statement
The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.
Similar articles
-
[Studies on chemical constituents of saponins from Panax ginseng flower buds].Zhongguo Zhong Yao Za Zhi. 2019 Jun;44(12):2519-2531. doi: 10.19540/j.cnki.cjcmm.20190321.206. Zhongguo Zhong Yao Za Zhi. 2019. PMID: 31359719 Chinese.
-
[Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province].Zhongguo Zhong Yao Za Zhi. 2013 Sep;38(17):2807-17. Zhongguo Zhong Yao Za Zhi. 2013. PMID: 24380303 Chinese.
-
Three new dammarane-type triterpene saponins from the leaves of Panax ginseng C.A. Meyer.J Asian Nat Prod Res. 2010 Oct;12(10):865-73. doi: 10.1080/10286020.2010.508035. J Asian Nat Prod Res. 2010. PMID: 20924900
-
Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds.J Korean Med Sci. 2001 Dec;16 Suppl(Suppl):S28-37. doi: 10.3346/jkms.2001.16.S.S28. J Korean Med Sci. 2001. PMID: 11748374 Free PMC article. Review.
-
Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy.Pharmacol Res. 2020 Nov;161:105263. doi: 10.1016/j.phrs.2020.105263. Epub 2020 Oct 27. Pharmacol Res. 2020. PMID: 33127555 Review.
Cited by
-
Metabolism of 20(S)-Ginsenoside Rg₂ by Rat Liver Microsomes: Bioactivation to SIRT1-Activating Metabolites.Molecules. 2016 Jun 10;21(6):757. doi: 10.3390/molecules21060757. Molecules. 2016. PMID: 27294899 Free PMC article.
-
Quality Evaluation of Polygonatum cyrtonema Hua Based on UPLC-Q-Exactive Orbitrap MS and Electronic Sensory Techniques with Different Numbers of Steaming Cycles.Foods. 2024 May 20;13(10):1586. doi: 10.3390/foods13101586. Foods. 2024. PMID: 38790887 Free PMC article.
-
Saponins of ginseng products: a review of their transformation in processing.Front Pharmacol. 2023 Apr 28;14:1177819. doi: 10.3389/fphar.2023.1177819. eCollection 2023. Front Pharmacol. 2023. PMID: 37188270 Free PMC article. Review.
-
High-Performance Liquid Chromatography with Diode Array Detector and Electrospray Ionization Ion Trap Time-of-Flight Tandem Mass Spectrometry to Evaluate Ginseng Roots and Rhizomes from Different Regions.Molecules. 2016 May 9;21(5):603. doi: 10.3390/molecules21050603. Molecules. 2016. PMID: 27171066 Free PMC article.
-
Advances in Saponin Diversity of Panax ginseng.Molecules. 2020 Jul 29;25(15):3452. doi: 10.3390/molecules25153452. Molecules. 2020. PMID: 32751233 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials
Miscellaneous