Fetal and neonatal effects of the beta-adrenoceptor blocking agents

Dev Pharmacol Ther. 1987;10(3):224-31. doi: 10.1159/000457747.


The placental transfer of beta-adrenoceptor blocking agents has been well established in the last years. Randomized and/or controlled studies have given a less pessimistic view of the consequences of these drugs on the fetal and neonatal adaptation. In fact, the beta-blockers are able to produce hypotension, bradycardia, respiratory troubles in the newborn infant, troubles which are generally slight when the neonates are full-term. However, even if in good clinical conditions, this kind of neonate should be carefully monitored for at least the first 2 days of life.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / adverse effects*
  • Adrenergic beta-Antagonists / metabolism
  • Blood Glucose / metabolism
  • Blood Pressure / drug effects
  • Female
  • Fetus / drug effects*
  • Fetus / physiology
  • Heart Rate / drug effects
  • Humans
  • Infant, Newborn
  • Maternal-Fetal Exchange
  • Pregnancy
  • Respiration / drug effects


  • Adrenergic beta-Antagonists
  • Blood Glucose