Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases

J Ethnopharmacol. 2018 Jan 10;210:296-310. doi: 10.1016/j.jep.2017.08.035. Epub 2017 Aug 31.

Abstract

Ethnopharmacological relevance: The compound epigallocatechin-3-gallate (EGCG), the major polyphenolic compound present in green tea [Camellia sinensis (Theaceae], has shown numerous cardiovascular health promoting activity through modulating various pathways. However, molecular understanding of the cardiovascular protective role of EGCG has not been reported.

Aim of the review: This review aims to compile the preclinical and clinical studies that had been done on EGCG to investigate its protective effect on cardiovascular and metabolic diseases in order to provide a systematic guidance for future research.

Materials and methods: Research papers related to EGCG were obtained from the major scientific databases, for example, Science direct, PubMed, NCBI, Springer and Google scholar, from 1995 to 2017.

Results: EGCG was found to exhibit a wide range of therapeutic properties including anti-atherosclerosis, anti-cardiac hypertrophy, anti-myocardial infarction, anti-diabetes, anti-inflammatory and antioxidant. These therapeutic effects are mainly associated with the inhibition of LDL cholesterol (anti-atherosclerosis), inhibition of NF-κB (anti-cardiac hypertrophy), inhibition of MPO activity (anti-myocardial infarction), reduction in plasma glucose and glycated haemoglobin level (anti-diabetes), reduction of inflammatory markers (anti-inflammatory) and the inhibition of ROS generation (antioxidant).

Conclusion: EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases was discussed.

Keywords: Anti-inflammatory; Antioxidant; Atherosclerosis; Diabetes; EGCG; Heart failure.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology
  • Camellia sinensis / chemistry
  • Cardiovascular Agents / isolation & purification
  • Cardiovascular Agents / pharmacology
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / physiopathology
  • Catechin / analogs & derivatives*
  • Catechin / isolation & purification
  • Catechin / pharmacology
  • Humans
  • Metabolic Diseases / drug therapy*
  • Metabolic Diseases / physiopathology
  • Tea / chemistry

Substances

  • Anti-Inflammatory Agents
  • Cardiovascular Agents
  • Tea
  • Catechin
  • epigallocatechin gallate