A new HindIII restriction fragment length polymorphism in the hemophilia A locus

Hum Genet. 1987 Jun;76(2):127-8. doi: 10.1007/BF00284907.


Using a fragment of the cDNA for human coagulation factor VIII as a hybridization probe, we have detected a new polymorphic HindIII site in intron 19 of the factor VIII gene. The frequency of the minor allele is 0.30. This polymorphism shows strong linkage disequilibrium with a previously described BclI polymorphism in intron 18.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Chromosome Mapping
  • DNA / genetics
  • DNA Restriction Enzymes*
  • Deoxyribonuclease HindIII
  • Factor VIII / genetics*
  • Female
  • Hemophilia A / genetics*
  • Humans
  • Introns
  • Male
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length*


  • Factor VIII
  • DNA
  • DNA Restriction Enzymes
  • Deoxyribonuclease HindIII