Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Nov;77(5):938-945.e4.
doi: 10.1016/j.jaad.2017.06.149. Epub 2017 Aug 29.

A Meta-Analysis of Nevus-Associated Melanoma: Prevalence and Practical Implications

Affiliations
Review

A Meta-Analysis of Nevus-Associated Melanoma: Prevalence and Practical Implications

Riccardo Pampena et al. J Am Acad Dermatol. .

Abstract

The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case-control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0.29-0.44; P < .001; I2 = 99%); nevus-associated melanomas had a lower mean Breslow thickness than de novo melanomas (mean difference -0.39 mm; 95% CI -0.60 to -0.18; P = .0003; I2 = 66%). No significant differences were noted regarding the association of nevus-associated melanomas with nondysplastic nevi or dysplastic nevi (risk ratio 0.77, 95% CI 0.49-1.20; P = .24; I2 = 98%).

Keywords: dysplastic nevus; melanoma; meta-analysis; nevus-associated; prevalence; thickness.

Similar articles

See all similar articles

Cited by 9 articles

See all "Cited by" articles

Supplementary concepts

Feedback