Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017;1006:61-82.
doi: 10.1007/978-4-431-56550-5_5.

Remodeling of Actin Filaments by Drebrin A and Its Implications

Affiliations
Review

Remodeling of Actin Filaments by Drebrin A and Its Implications

Elena E Grintsevich. Adv Exp Med Biol. .

Abstract

Dendritic spines are small protrusions of dendrites that are critical for synaptic transmission. The plasticity and stability of dendritic spines is tightly linked to actin cytoskeleton. However, our understanding of specific properties and the fine-tuning of neuronal actin structures is incomplete. Drebrin A is highly enriched in dendritic spines, but its effects on actin morphology, dynamics, and interplay with other actin regulators are yet to be clarified. Here we review recent advances in understanding drebrin effects on actin morphology and dynamics.

Keywords: Actin; Actin dynamics; Binding kinetics; Cooperativity; Drebrin; Mapping.

Similar articles

See all similar articles

Cited by 2 articles

Publication types

LinkOut - more resources

Feedback