Drebrin Regulation of Calcium Signaling in Immune Cells

Adv Exp Med Biol. 2017;1006:281-290. doi: 10.1007/978-4-431-56550-5_16.

Abstract

Store-operated Ca2+ channels are plasma membrane channels that are activated by depletion of intracellular Ca2+ stores, resulting in an increase in intracellular Ca2+; however, little is known about their regulation. Our work has shown that the immunosuppressant compound BTP2, which blocks Ca2+ influx into cells, interacts with the actin-reorganizing protein, drebrin. Here we review the role of drebrin in the regulation of calcium signaling, with a focus on immune cells.

Keywords: Acute IgE challenge; BTP2; FcεRI-mediated actin organization; Filopodia extension; Jurkat T cells; Store-operated Ca2+ channel.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Actins / immunology
  • Actins / metabolism
  • Animals
  • Calcium / metabolism*
  • Calcium Channels / genetics
  • Calcium Channels / metabolism*
  • Calcium Signaling / drug effects
  • Calcium Signaling / genetics*
  • Cell Membrane / metabolism
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Jurkat Cells / immunology
  • Neuropeptides / immunology
  • Neuropeptides / metabolism*

Substances

  • Actins
  • Calcium Channels
  • Immunosuppressive Agents
  • Neuropeptides
  • drebrins
  • Calcium