Chronobiologic Aspects of Venous Thromboembolism

Heart Fail Clin. 2017 Oct;13(4):691-696. doi: 10.1016/j.hfc.2017.05.005. Epub 2017 Jun 26.


In recent years, several studies have consistently described the chronobiologic aspects of many cardiovascular diseases. Several studies have also assessed the circadian and circannual patterns of occurrence and mortality of deep vein thrombosis and pulmonary embolism, but the results have been less univocal. Different mechanisms have been proposed to explain these possible patterns, including oscillation of coagulation proteins, the role of meteorologic parameters, and air pollution. This article summarizes the available evidence on chronobiologic aspects of venous thromboembolism and discusses the casual mechanism.

Keywords: Chronobiology; Circadian; Circannual; Deep vein thrombosis; Pulmonary embolism.

Publication types

  • Review

MeSH terms

  • Circadian Rhythm / physiology*
  • Humans
  • Seasons*
  • Venous Thromboembolism / physiopathology*