Cavin-2 is a specific marker for detection of well-differentiated liposarcoma

Biochem Biophys Res Commun. 2017 Nov 4;493(1):660-665. doi: 10.1016/j.bbrc.2017.08.135. Epub 2017 Sep 1.


Caveolae are cholesterol enriched invaginations of the plasma membrane involved in a variety of processes, including glucose and fatty acids absorption, cell transduction and mechanoprotection. The biogenesis and function of caveolae depend on the activity of Caveolin (Cav-1, -2 and -3) and Cavin (Cavin-1, -2, -3 and -4) protein families. Since the membrane Cavin-2 protein was reported to play a key role in caveolae formation of adipocytes, in this work we have used a multidisciplinary approach to investigate its expression in liposarcoma (LPS), an adipocytic soft tissue sarcoma affecting adults. Data obtained through an in silico and immunohistochemical analysis suggest that Cavin-2, along with Cavin-1, Cav-1 and Cav-2, is mostly expressed in the least aggressive LPS subtype, namely well-differentiated LPS, while is almost undetectable in the more aggressive myxoid, pleomorphic and dedifferentiated LPS tumors. Accordingly, in vitro analysis confirmed that Cavin-2 expression increases in LPS tumor cell lines during differentiation as compared to proliferation, as detected by immunoblotting and immunofluorescence analysis. Overall, these data suggest that Cavin-2 represents a useful marker for discriminating the degree of differentiation in LPS tumors.

Keywords: Adipocytes; Caveolae; Caveolins; Cavin-2; Cavins; Liposarcoma.

MeSH terms

  • Animals
  • Biomarkers, Tumor / metabolism*
  • Carrier Proteins / metabolism*
  • Cell Line, Tumor
  • Humans
  • Liposarcoma / metabolism*
  • Liposarcoma / pathology*
  • Mice
  • Neoplasm Proteins / metabolism
  • Phosphate-Binding Proteins
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Species Specificity


  • Biomarkers, Tumor
  • CAVIN2 protein, human
  • Carrier Proteins
  • Neoplasm Proteins
  • Phosphate-Binding Proteins