The association between insulin resistance and atrial fibrillation: A cross-sectional analysis from SPRINT (Systolic Blood Pressure Intervention Trial)

J Clin Hypertens (Greenwich). 2017 Nov;19(11):1152-1161. doi: 10.1111/jch.13062. Epub 2017 Sep 3.


It is unclear whether metabolic syndrome (MetS) is associated with atrial fibrillation (AF) in an older population with greater cardiovascular risk, including those with chronic kidney disease. The authors investigated the association between MetS and AF in participants in SPRINT (Systolic Blood Pressure Intervention Trial). MetS was defined based on the Modified Third National Cholesterol Education Program. The baseline prevalence rate for MetS was 55%, while 8.2% of the participants had AF. In multivariate regression analyses, AF was not associated with presence of MetS in either chronic kidney disease or non-chronic kidney disease subgroups. Age, race, history of cardiovascular diseases, decreased triglycerides, decreased pulse pressure, and albuminuria remained significantly associated with AF risk. In contrast to the general population, MetS was not associated with AF in the older population with increased cardiovascular risk studied in SPRINT.

Keywords: chronic renal failure; insulin resistance; metabolic syndrome.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Albuminuria / epidemiology*
  • Atrial Fibrillation* / diagnosis
  • Atrial Fibrillation* / epidemiology
  • Blood Pressure*
  • Female
  • Humans
  • Hypertension* / epidemiology
  • Hypertension* / metabolism
  • Hypertension* / physiopathology
  • Hypertension* / therapy
  • Insulin Resistance*
  • Male
  • Metabolic Syndrome* / diagnosis
  • Metabolic Syndrome* / epidemiology
  • Prevalence
  • Renal Insufficiency, Chronic* / diagnosis
  • Renal Insufficiency, Chronic* / epidemiology
  • Risk Factors
  • Statistics as Topic
  • Triglycerides / analysis*


  • Triglycerides

Associated data

  • GENBANK/TR000445