Birth and Death of Histone mRNAs

William F Marzluff; Kaitlin P Koreski

doi:10.1016/j.tig.2017.07.014

Birth and Death of Histone mRNAs

Trends Genet. 2017 Oct;33(10):745-759. doi: 10.1016/j.tig.2017.07.014. Epub 2017 Aug 31.

Authors

William F Marzluff¹, Kaitlin P Koreski²

Affiliations

¹ Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: marzluff@med.unc.edu.
² Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

In metazoans, histone mRNAs are not polyadenylated but end in a conserved stem-loop. Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in histone mRNA metabolism. The genes for the five histone proteins are linked. A histone locus body (HLB) forms at each histone gene locus. It contains factors essential for transcription and processing of histone mRNAs, and couples transcription and processing. The active form of U7 snRNP contains the HLB component FLASH (FLICE-associated huge protein), the histone cleavage complex (HCC), and a subset of polyadenylation factors including the endonuclease CPSF73. Histone mRNAs are rapidly degraded when DNA replication is inhibited by a 3' to 5' pathway that requires extensive uridylation of mRNA decay intermediates.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Animals
Histones / genetics*
RNA, Messenger / genetics*

Substances

Histones
RNA, Messenger

Abstract

Publication types

MeSH terms

Substances

Grants and funding