Prenatal Risk Factors for PHACE Syndrome: A Study Using the PHACE Syndrome International Clinical Registry and Genetic Repository

J Pediatr. 2017 Nov;190:275-279. doi: 10.1016/j.jpeds.2017.06.055. Epub 2017 Sep 1.


The cause of PHACE syndrome is unknown. In a study of 218 patients, we examined potential prenatal risk factors for PHACE syndrome. Rates of pre-eclampsia and placenta previa in affected individuals were significantly greater than in the general population. No significant risk factor differences were detected between male and female subjects.

Keywords: disease pathogenesis; hemangioma; perinatal risk factors.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aortic Coarctation / epidemiology
  • Aortic Coarctation / etiology*
  • Cross-Sectional Studies
  • Eye Abnormalities / epidemiology
  • Eye Abnormalities / etiology*
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Neurocutaneous Syndromes / epidemiology
  • Neurocutaneous Syndromes / etiology*
  • Placenta Previa
  • Pre-Eclampsia
  • Pregnancy
  • Prenatal Care / statistics & numerical data
  • Registries
  • Risk Factors
  • United States / epidemiology

Supplementary concepts

  • PHACE association