PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression

Leslie Ann Caromile; Linda H Shapiro

doi:10.1080/23723556.2017.1321168

PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression

Mol Cell Oncol. 2017 Apr 28;4(4):e1321168. doi: 10.1080/23723556.2017.1321168. eCollection 2017.

Authors

Leslie Ann Caromile¹, Linda H Shapiro¹

Affiliation

¹ Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT, USA.

Abstract

Increased Prostate Specific Membrane Antigen expression promotes tumor progression in prostate epithelium by dysregulating the β1-integrin/type I insulin-like growth factor receptor axis, resulting in a shift in signaling from the less aggressive mitogen-activated protein kinase-extracellular signal-regulated kinases 1 and 2 pathway to the pro-survival protein kinase B(AKT)/phosphatidylinositol 3-kinase pathway.

Keywords: MAPK; PI3K-AKT; PSMA; Prostate Cancer; Tumor.

Grants and funding

K01 CA188412/CA/NCI NIH HHS/United States