SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer

Mol Cell Oncol. 2017 Jun 19;4(4):e1342747. doi: 10.1080/23723556.2017.1342747. eCollection 2017.


Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

Keywords: BAF180; Clear Cell Kidney Cancer Mouse Model; Genomic Biomarkers; MTOR; PBRM1; SWI/SNF Chromatin Remodeling Tumor Suppressor Gene; VHL.