NMDA receptor antagonist D-APV depresses excitatory activity produced by normorphine in rat hippocampal slices

Neurosci Lett. 1987 Jul 9;78(1):80-4. doi: 10.1016/0304-3940(87)90565-9.

Abstract

Both pentylenetetrazole and normorphine increased CA1 pyramidal cell sensitivity to afferent stimulation and caused the appearance of synchronous afterpotentials (secondary spikes). D-2-Amino-5-phosphonovalerate (D-APV) attenuated secondary spikes induced by both drugs, but had no effect on the change in excitability of the primary population spike. These results suggest that both opiates and GABA receptor antagonists are able to unmask NMDA receptors in the in vitro rat hippocampus slice preparation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Amino-5-phosphonovalerate
  • Animals
  • Hippocampus / drug effects*
  • In Vitro Techniques
  • Male
  • Morphine Derivatives / antagonists & inhibitors*
  • Morphine Derivatives / pharmacology
  • Pentylenetetrazole / antagonists & inhibitors
  • Pentylenetetrazole / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / drug effects*
  • Valine / analogs & derivatives*
  • Valine / pharmacology

Substances

  • Morphine Derivatives
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • 2-Amino-5-phosphonovalerate
  • Valine
  • Pentylenetetrazole
  • normorphine