Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering

Hong Zhao; Ruihua Ding; Xin Zhao; Yiwei Li; Liangliang Qu; Hao Pei; Lara Yildirimer; Zhengwei Wu; Weixia Zhang

doi:10.1016/j.drudis.2017.04.002

Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering

Drug Discov Today. 2017 Sep;22(9):1302-1317. doi: 10.1016/j.drudis.2017.04.002. Epub 2017 Sep 1.

Authors

Hong Zhao¹, Ruihua Ding², Xin Zhao³, Yiwei Li⁴, Liangliang Qu⁵, Hao Pei⁵, Lara Yildirimer⁶, Zhengwei Wu⁷, Weixia Zhang⁸

Affiliations

¹ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Research Institute of Petroleum Processing, SINOPEC, Beijing 100083, China.
² John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
³ Interdisciplinary Division of Biomedical Engineering, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
⁴ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁵ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
⁶ Barnet General Hospital Royal Free NHS Trust Hospital, Wellhouse Lane, Barnet EN5 3DJ, UK.
⁷ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Department of Biomedical Engineering and Biotechnology, University of Massachusetts Lowell, Lowell, MA 01854, USA.
⁸ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. Electronic address: wxzhang@seas.harvard.edu.

PMID: 28869820
DOI: 10.1016/j.drudis.2017.04.002

Abstract

Here, we discuss the biomedical applications of graphene-based nanomaterials (GBNs). We examine graphene and its various derivatives, including graphene, graphene oxides (GOs), reduced graphene oxides (rGOs), graphene quantum dots (GQDs), and graphene composites, and discuss their unique properties related to their biomedical applications. We also summarize the detailed biomedical applications of GBNs, including drug and/or gene delivery, bioimaging, and tissue engineering. We also highlight the toxicity of these nanomaterials.

Publication types

Review

MeSH terms

Animals
Diagnostic Imaging
Drug Delivery Systems
Gene Transfer Techniques
Graphite / administration & dosage*
Graphite / chemistry
Humans
Nanostructures / administration & dosage*
Nanostructures / chemistry
Tissue Engineering

Substances

Graphite