Reflex decreases in intragastric pressure in response to cholecystokinin in rats

Am J Physiol. 1987 Aug;253(2 Pt 1):G165-70. doi: 10.1152/ajpgi.1987.253.2.G165.


The actions of intravenous sulfated cholecystokinin octapeptide (CCK-8) on intraluminal pressure in the body of the stomach were studied in urethan-anesthetized rats. There was a dose-related decrease in pressure in response to CCK-8 over the range 0.3-33 pmol. Bilateral cervical vagotomy alone reduced the response to CCK-8 and together with splanchnic section abolished it. Hexamethonium also reduced the response. Vagotomy did not change the response to CCK-8 in hexamethonium-treated rats, but celiac ganglionectomy abolished it. Guanethidine and phentolamine, but not propranolol, significantly decreased the response to CCK-8; subsequent vagotomy abolished the response. Similarly, depletion of tissue catecholamines by pretreatment with 6-OH dopamine, reserpine, or celiac ganglionectomy together with vagal section abolished the effect of CCK-8. It concluded that CCK-8 decreases mean intragastric pressure in the rat by pathways involving both vagal and splanchnic nerves. The splanchnic pathway involves an alpha-adrenergic mechanism but is hexamethonium resistant. The vagal pathway is hexamethonium sensitive and nonadrenergic. Similar pathways may mediate the effect of CCK on gastric emptying.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cholecystokinin / pharmacology*
  • Denervation
  • Dose-Response Relationship, Drug
  • Hexamethonium
  • Hexamethonium Compounds / pharmacology
  • Male
  • Norepinephrine / metabolism
  • Pressure
  • Rats
  • Reflex*
  • Sincalide / pharmacology
  • Splanchnic Nerves / physiology
  • Stomach / drug effects*
  • Stomach / physiology
  • Sympatholytics / pharmacology
  • Vagotomy


  • Hexamethonium Compounds
  • Sympatholytics
  • Hexamethonium
  • Cholecystokinin
  • Sincalide
  • Norepinephrine