The Impact of Histologic Phenotype in the Treatment of Sinonasal Cancer

Adv Ther. 2017 Oct;34(10):2181-2198. doi: 10.1007/s12325-017-0605-9. Epub 2017 Sep 4.


The management of sinonasal cancer is a challenge due to its low occurrence and anatomical and significant diversity of histological types. The therapeutic modality used should be tailored individually according to the histology, tumour stage, molecular profile and previous treatments. The clinical management of sinonasal cancer has improved greatly owing to developments in endoscopic surgery and precision radiotherapy. Complete surgical resection is the mainstay of sinonasal malignancies' management but multimodality therapy is associated with improved outcomes in certain histologies. The recognition of various histological types with biological behaviours more suitable for non-surgical modalities has allowed treatment protocols to become more tailored to the disease. In this review we aim to describe and to summarise the current data guiding the management of sinonasal cancer with emphasis on phenotypic variation.

Keywords: Endoscopic surgery; Histology; Oncology; Paranasal cavities; Radiotherapy; Sinonasal cancer.

Publication types

  • Review

MeSH terms

  • Combined Modality Therapy
  • Drug Therapy / methods*
  • Female
  • Humans
  • Male
  • Paranasal Sinus Neoplasms / genetics*
  • Paranasal Sinus Neoplasms / therapy*
  • Phenotype*
  • Radiotherapy / methods*