Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study

Head Neck. 2017 Nov;39(11):2232-2240. doi: 10.1002/hed.24886. Epub 2017 Sep 4.


Background: Using the thoroughly validated Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO) questionnaire, the purpose of this study was to investigate changes in disease-specific quality of life (QOL) after surgical treatment in patients with benign nontoxic multinodular goiters.

Method: Patients with goiters scheduled for thyroid surgery (n = 106) and individuals from the general population (n = 739) were studied. The ThyPRO data before, 3 months, and 6 months after surgery were compared with normative scores from the general population using a linear mixed model and t tests.

Results: Before surgery, patients with goiters experienced poorer scores on all scales compared to the general population. After surgery, moderate to large improvements were seen in goiter symptoms, tiredness, anxiety, and overall QOL. After surgery, all scales returned to values equal to the general population. The degree of anxiety was, in fact, lower than in the general population.

Conclusion: Thyroid surgery leads to significant benefit among patients with benign nontoxic goiters by restoring QOL equal to that in the general population.

Keywords: Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO); goiter; quality of life; surgery; thyroid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anxiety / etiology
  • Anxiety / prevention & control
  • Cohort Studies
  • Denmark
  • Disorders of Excessive Somnolence / etiology
  • Disorders of Excessive Somnolence / prevention & control
  • Female
  • Goiter, Nodular / complications
  • Goiter, Nodular / psychology
  • Goiter, Nodular / surgery*
  • Humans
  • Male
  • Middle Aged
  • Patient Reported Outcome Measures
  • Quality of Life*
  • Thyroidectomy*