Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults

Clin Exp Hypertens. 2018;40(3):244-250. doi: 10.1080/10641963.2017.1356845. Epub 2017 Sep 5.


Background: To identify one of the physiological underlying mechanisms of the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP) for the onset of cardiovascular disease (CVD), we investigated the relationship between urinary L-FABP levels and subendocardial viability ratio (SEVR), a marker of myocardial perfusion, in middle- and older-aged adults.

Methods: This was a cross-sectional study of 249 middle- and older-aged adults (aged 46-83 years). We measured urinary L-FABP levels and central hemodynamic parameters, including SEVR, calculated by pulse wave analysis using an applanation tonometry.

Results: In the participants stratified in accordance with the tertiles of urinary L-FABP levels, SEVR decreased in a stepwise fashion with increasing tertiles (p < 0.001). Furthermore, this association remains significant after the consideration of various confounders. On the contrary, urinary albumin levels were not independently related with SEVR.

Conclusion: Our results demonstrated that urinary L-FABP levels were independently associated with the SEVR of the middle- and older-aged adults. This result suggests that the increase in urinary L-FABP levels even within the normal range might be related to the decrease in myocardial perfusion (SEVR).

Keywords: Cardiovascular disease; intra-renal microcirculation; myocardial perfusion; pulse wave analysis; tubular biomarker.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Albuminuria / urine
  • Biomarkers / urine
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular Diseases / urine*
  • Coronary Circulation*
  • Cross-Sectional Studies
  • Fatty Acid-Binding Proteins / urine*
  • Female
  • Hemodynamics*
  • Humans
  • Male
  • Middle Aged
  • Pulse Wave Analysis


  • Biomarkers
  • FABP1 protein, human
  • Fatty Acid-Binding Proteins