Sodium Thiosulfate in the Treatment of Lung and Breast Calciphylaxis: CT and Bone Scintigraphy Findings

Clin Nucl Med. 2017 Nov;42(11):893-895. doi: 10.1097/RLU.0000000000001837.


A 19-year-old woman, with normal kidney function, was diagnosed as having visceral calciphylaxis, especially diffuse breast and lung calcification. The calcification findings were clearly shown on CT, and bone scintigraphy revealed diffuse uptake in the thoracic area. Although there was no standard therapeutic approach for this clinical setting, the patient received empiric therapy with sodium thiosulfate. After 5 months of consecutive therapy, the calcification condition had a striking regression.

Publication types

  • Case Reports

MeSH terms

  • Bone and Bones / diagnostic imaging*
  • Breast Diseases / diagnostic imaging*
  • Breast Diseases / drug therapy
  • Calciphylaxis / diagnosis
  • Calciphylaxis / diagnostic imaging*
  • Calciphylaxis / drug therapy
  • Female
  • Humans
  • Lung Diseases / diagnostic imaging*
  • Lung Diseases / drug therapy
  • Radionuclide Imaging
  • Thiosulfates / therapeutic use*
  • Tomography, X-Ray Computed*
  • Young Adult


  • Thiosulfates
  • sodium thiosulfate