C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor

Elife. 2017 Sep 5;6:e23770. doi: 10.7554/eLife.23770.

Abstract

Predators and prey co-evolve, each maximizing their own fitness, but the effects of predator-prey interactions on cellular and molecular machinery are poorly understood. Here, we study this process using the predator Caenorhabditis elegans and the bacterial prey Streptomyces, which have evolved a powerful defense: the production of nematicides. We demonstrate that upon exposure to Streptomyces at their head or tail, nematodes display an escape response that is mediated by bacterially produced cues. Avoidance requires a predicted G-protein-coupled receptor, SRB-6, which is expressed in five types of amphid and phasmid chemosensory neurons. We establish that species of Streptomyces secrete dodecanoic acid, which is sensed by SRB-6. This behavioral adaptation represents an important strategy for the nematode, which utilizes specialized sensory organs and a chemoreceptor that is tuned to recognize the bacteria. These findings provide a window into the molecules and organs used in the coevolutionary arms race between predator and potential prey.

Keywords: C. elegans; Streptomyces; dodecanoic acid; neuroscience; phasmid; predator; prey; srb-6.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / microbiology
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins / metabolism*
  • Chemoreceptor Cells / physiology*
  • Chemotaxis
  • Neurons / cytology
  • Neurons / microbiology
  • Neurons / physiology*
  • Phylogeny
  • Signal Transduction
  • Streptomyces / pathogenicity*

Substances

  • Caenorhabditis elegans Proteins