Game of TOR - The Target of Rapamycin Rules Four Kingdoms

N Engl J Med. 2017 Sep 28;377(13):1297-9. doi: 10.1056/NEJMcibr1709384. Epub 2017 Sep 5.

Author

Brendan D Manning¹

Affiliation

¹ From the Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston.

PMID: 28874074
DOI: 10.1056/NEJMcibr1709384

No abstract available

MeSH terms

Drug Resistance, Fungal / genetics*
Mechanistic Target of Rapamycin Complex 1
Multiprotein Complexes / metabolism
Mutation
Saccharomyces cerevisiae / drug effects
Saccharomyces cerevisiae / genetics*
Sirolimus / chemistry
Sirolimus / pharmacology*
T-Lymphocytes / metabolism
TOR Serine-Threonine Kinases / genetics*
TOR Serine-Threonine Kinases / metabolism

Substances

Multiprotein Complexes
Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases
Sirolimus