Glycans in Acquired Human Diseases

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015–2017. Chapter 46.


Many noninherited human diseases are caused or influenced by acquired changes in glycan synthesis or recognition. This chapter lists a few examples, their proposed mechanisms, and a few therapies. Knowing the altered glycans or changes in glycan-binding proteins, and whether or not they are the primary cause, can improve diagnosis or therapies. Glycosylation changes in cancer and in inherited human genetic disorders are discussed separately in Chapters 47 and 45, respectively.

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