Pd-Catalyzed Thiophene-Aryl Coupling Reaction via C-H Bond Activation in Deep Eutectic Solvents

Org Lett. 2017 Sep 15;19(18):4754-4757. doi: 10.1021/acs.orglett.7b02114. Epub 2017 Sep 6.


Direct arylation of 5-octylthieno[3,4-c]pyrrole-4,6-dione with a series of functionalized aryl iodides via C-H bond activation is demonstrated in a deep eutectic solvent made of choline chloride and urea in non-anhydrous conditions and without exclusion of air. This is the first demonstration of a thiophene-aryl coupling via direct arylation in deep eutectic solvents.

Publication types

  • Research Support, Non-U.S. Gov't