Successful treatment of primary hyperoxaluria type I by combined hepatic and renal transplantation

Lancet. 1987 Aug 29;2(8557):474-5. doi: 10.1016/s0140-6736(87)91791-0.

Abstract

A patient with primary hyperoxaluria type 1 (hepatic peroxisomal alanine:glyoxylate aminotransferase [EC 2.6.1.44] deficiency) was successfully treated by combined hepatic and renal transplantation. The metabolic lesion was corrected by replacement of the deficient hepatic enzyme activity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alanine Transaminase / deficiency*
  • Evaluation Studies as Topic
  • Humans
  • Hyperoxaluria / therapy*
  • Kidney Transplantation*
  • Liver / enzymology
  • Liver Transplantation*
  • Male
  • Oxalates / metabolism
  • Postoperative Complications
  • Transaminases*

Substances

  • Oxalates
  • Transaminases
  • Alanine Transaminase
  • Alanine-glyoxylate transaminase