Absence of cell surface LFA-1 as a mechanism of escape from immunosurveillance

Lancet. 1987 Sep 5;2(8558):533-6. doi: 10.1016/s0140-6736(87)92924-2.


During studies of T-cell recognition of autologous tumour cells, a number of tumour cell lines derived from patients with lymphoma proved to be poor stimulators of both autologous and allogeneic T-cell responses. Analysis of the tumour cell surface molecules indicated that expression of the lymphocyte-function-associated antigen, LFA-1, was lacking, whereas normal leucocytes from these patients expressed normal levels of LFA-1. Examination of other lymphoid tumours revealed that most high grade lymphomas, but not most low or intermediate grade lymphomas, do not express the LFA-1 molecule. Furthermore, in an initial survey, the tumours from 5 of 7 patients with non-relapsing large cell lymphomas expressed LFA-1 whereas only 3 of 18 patients with relapsing lymphomas had tumours that did so. These findings suggest that tumour cells lacking surface LFA-1 cannot initiate an effective immune response in vivo. This lack of immunogenicity might contribute to escape from immunosurveillance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Surface / analysis*
  • B-Lymphocytes / immunology
  • Burkitt Lymphoma / immunology
  • Cell Membrane / immunology
  • Humans
  • Lymphocyte Culture Test, Mixed
  • Lymphocyte Function-Associated Antigen-1
  • Lymphoma / immunology*
  • T-Lymphocytes / immunology


  • Antigens, Surface
  • Lymphocyte Function-Associated Antigen-1