DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells

Clin Immunol. 2017 Oct;183:263-265. doi: 10.1016/j.clim.2017.08.020. Epub 2017 Sep 4.
No abstract available

Keywords: CpG; DOCK8; Hyper IgE Syndrome; IgE synthesis; STAT3.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes / drug effects
  • B-Lymphocytes / immunology*
  • CD40 Antigens / immunology
  • Cells, Cultured
  • Guanine Nucleotide Exchange Factors / immunology*
  • Humans
  • Immunoglobulin Class Switching
  • Immunoglobulin E / immunology*
  • Interleukin-4 / pharmacology
  • Job Syndrome / immunology
  • Oligodeoxyribonucleotides / pharmacology
  • STAT3 Transcription Factor / immunology*
  • Toll-Like Receptor 9 / immunology*

Substances

  • CD40 Antigens
  • DOCK8 protein, human
  • Guanine Nucleotide Exchange Factors
  • Oligodeoxyribonucleotides
  • ProMune
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • TLR9 protein, human
  • Toll-Like Receptor 9
  • Interleukin-4
  • Immunoglobulin E