SCARB1 Gene Polymorphisms and HDL Subfractions in Coronary Artery Disease

In Vivo. 2017 Sep-Oct;31(5):873-876. doi: 10.21873/invivo.11141.

Abstract

Background/aim: Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Polymorphisms in the SCARB1 gene are known to be related to plasma lipids.

Patients and methods: Real time-polymerase chain reaction (RT-PCR) was used for identification of SCARB1 polymorphisms and the Lipoprint Quantimetrix System was employed in identification of HDL subfractions.

Results: According to allelic distribution, in both groups SCARB1 AA genotype led to a two-fold decrease in the risk of developing cardiovascular disease (p=0.04), while the GA genotype increased the risk two-fold (p=0.03). According to the HDL subfraction analysis results, the AA genotype had higher levels of big-sized HDL subfraction (p=0.02).

Conclusion: The SCARB1AA genotype decreased cardiovascular risk and carrying GA genotype and G allele increased the risk of CAD. AA genotype carriers had higher levels of big-sized HDL subfraction.

Keywords: Coronary artery disease; HDL subfractions; SCARB1; polymorphism.

MeSH terms

  • Aged
  • Alleles
  • Case-Control Studies
  • Comorbidity
  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / metabolism*
  • Disease Susceptibility*
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genotype
  • Humans
  • Lipoproteins, HDL / metabolism*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Scavenger Receptors, Class B / genetics*

Substances

  • Lipoproteins, HDL
  • SCARB1 protein, human
  • Scavenger Receptors, Class B