Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice

Sci Rep. 2017 Sep 7;7(1):10847. doi: 10.1038/s41598-017-11457-w.


The present work was designed to investigate the antihyperglycaemic and protective effects of two Hericium erinaceus intracellular polysaccharide (HIPS) purified fractions (HIPS1 and HIPS2) from mycelia of H. erinaceus SG-02 on pancreas, liver and kidney in streptozotocin (STZ)-induced diabetic mice. The supplementation of HIPS1 and HIPS2 significantly decreased the blood glucose (GLU) levels; suppressed the abnormal elevations of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN) and creatinine (CRE) levels in serum; improved the antioxidant enzymatic (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)) activities; and attenuated the pathological damage to these organs. The HIPS1 showed superior effects in antihyperglycaemia and organic protection than HIPS2 possible owing to the abundant functional groups (-NH2, -COOH and S=O) in HIPS1, indicating that H. erinaceus SG-02 could be used as a functional food and natural drug for the prevention of diabetes and its complications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basidiomycota / chemistry*
  • Biomarkers
  • Diabetes Mellitus, Experimental
  • Disease Models, Animal
  • Fungal Polysaccharides / pharmacology*
  • Glycoside Hydrolase Inhibitors
  • Hypoglycemic Agents / pharmacology*
  • Kidney / drug effects*
  • Kidney / metabolism
  • Kidney / pathology
  • Liver / drug effects*
  • Liver / metabolism
  • Liver / pathology
  • Mice
  • Oxidation-Reduction
  • Pancreas / drug effects*
  • Pancreas / metabolism
  • Pancreas / pathology
  • Protective Agents / pharmacology*
  • Spectrum Analysis
  • alpha-Amylases / antagonists & inhibitors
  • alpha-Glucosidases / metabolism


  • Biomarkers
  • Fungal Polysaccharides
  • Glycoside Hydrolase Inhibitors
  • Hypoglycemic Agents
  • Protective Agents
  • alpha-Amylases
  • alpha-Glucosidases