Female offspring born to obese and insulin-resistant dams are not at increased risk for obesity and metabolic dysfunction during early development

Can J Physiol Pharmacol. 2018 Jan;96(1):97-102. doi: 10.1139/cjpp-2017-0371. Epub 2017 Sep 8.


The percentage of women who are obese at the time of conception or during pregnancy is increasing, with animal and human studies demonstrating that offspring born to obese dams or mothers are at increased risk for obesity and the metabolic syndrome. Our goal was to confirm in an experimental model of metabolic syndrome in the dam, whether the offspring would be at increased risk of obesity. Conversely, we observed that male offspring born to dams with metabolic syndrome had no alterations in their body mass profiles, whereas female offspring born to dams with metabolic syndrome were heavier at weaning, but exhibited no perturbations in energy metabolism. Moreover, they gained weight at a reduced rate versus female offspring born to healthy dams, and thus weighed less at study completion. Hence, our findings suggest that factors other than increased adiposity and insulin resistance during pregnancy are responsible for the increased risk of obesity in children born to obese mothers.

Keywords: glucose homeostasis; grossesse; high-fat diet; homéostasie du glucose; metabolic syndrome; obesity; obésité; offspring; pregnancy; rejetons; régime alimentaire à haute teneur en matières grasses; syndrome métabolique.

MeSH terms

  • Adiposity
  • Animals
  • Animals, Newborn
  • Blood Glucose / metabolism
  • Body Weight
  • Diet, High-Fat
  • Energy Metabolism
  • Female
  • Growth and Development*
  • Homeostasis
  • Insulin Resistance*
  • Metabolic Syndrome / complications*
  • Mice, Inbred C57BL
  • Obesity / complications*
  • Obesity / pathology
  • Risk Factors
  • Weaning
  • Weight Gain / drug effects


  • Blood Glucose