Cell therapies for Chagas disease

Cytotherapy. 2017 Nov;19(11):1339-1349. doi: 10.1016/j.jcyt.2017.07.014. Epub 2017 Sep 5.


In this review of cell therapies in Chagas disease, we cover aspects related to the disease, its treatment and world demographics, before proceeding to describe the preclinical and clinical trials performed using cell therapies in the search for an alternative therapy for the most severe and lethal form of this disease, chronic chagasic cardiomyopathy.

Keywords: Chagas disease; bone marrow cells; cardiomyopathy; cell therapy; mesenchymal stromal cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Marrow Transplantation / methods
  • Cell- and Tissue-Based Therapy / methods*
  • Chagas Cardiomyopathy / therapy
  • Chagas Disease / epidemiology
  • Chagas Disease / etiology
  • Chagas Disease / therapy*
  • Clinical Trials as Topic
  • Disease Models, Animal
  • Heart Transplantation
  • Humans
  • Mice