DNA polymorphism of human HLA-linked complement C4 allotypes, including C4 null alleles, in the Finnish population

Hum Hered. 1987;37(4):241-9. doi: 10.1159/000153711.


Human HLA-linked complement C4 gene products, C4A and C4B, show extensive genetic polymorphism. In both loci, an allele without a gene product, C4 null, is also observed. We have performed a restriction enzyme analysis of genomic DNA samples from individuals having all common (frequency over 1%) C4 protein allotypes observed in the Finnish population. Only one allotype-specific RFLP marker was observed. With some enzymes a DNA polymorphism was observed, which was not detectable by C4 protein typing. Analysis of 10 different C4B null haplotypes and 4 C4A null haplotypes suggested that only one haplotype, HLA-B8 C4A0 B1, carried a C4A gene deletion. This was observed in all 4 unrelated individuals homozygous for this haplotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Chromosome Deletion
  • Complement C4 / genetics*
  • Complement C4a
  • Complement C4b
  • DNA / genetics
  • Finland
  • Genetic Linkage
  • HLA Antigens / genetics*
  • Haplotypes
  • Humans
  • Polymorphism, Restriction Fragment Length


  • Complement C4
  • HLA Antigens
  • Complement C4a
  • Complement C4b
  • DNA