Peripheral Neuropathy and Nerve Compression Syndromes in Burns

Clin Plast Surg. 2017 Oct;44(4):793-803. doi: 10.1016/j.cps.2017.05.010. Epub 2017 Jul 21.


Peripheral neuropathy and nerve compression syndromes lead to substantial morbidity following burn injury. Patients present with pain, paresthesias, or weakness along a specific nerve distribution or experience generalized peripheral neuropathy. The symptoms manifest at various times from within one week of hospitalization to many months after wound closure. Peripheral neuropathy may be caused by vascular occlusion of vasa nervorum, inflammation, neurotoxin production leading to apoptosis, and direct destruction of nerves from the burn injury. This article discusses the natural history, diagnosis, current treatments, and future directions for potential interventions for peripheral neuropathy and nerve compression syndromes related to burn injury.

Keywords: Nerve compression syndromes; Peripheral nerves; Peripheral neuropathy.

Publication types

  • Review

MeSH terms

  • Analgesics, Opioid / therapeutic use
  • Burns / complications*
  • Humans
  • Nerve Compression Syndromes / diagnosis
  • Nerve Compression Syndromes / etiology
  • Nerve Compression Syndromes / surgery*
  • Pain / etiology
  • Peripheral Nervous System Diseases / diagnosis
  • Peripheral Nervous System Diseases / drug therapy*
  • Peripheral Nervous System Diseases / etiology
  • Peripheral Nervous System Diseases / physiopathology


  • Analgesics, Opioid