Bacterial conjugated linoleic acid production and their applications

Bo Yang; He Gao; Catherine Stanton; R Paul Ross; Hao Zhang; Yong Q Chen; Haiqin Chen; Wei Chen

doi:10.1016/j.plipres.2017.09.002

Bacterial conjugated linoleic acid production and their applications

Prog Lipid Res. 2017 Oct:68:26-36. doi: 10.1016/j.plipres.2017.09.002. Epub 2017 Sep 7.

Authors

Bo Yang¹, He Gao², Catherine Stanton³, R Paul Ross⁴, Hao Zhang¹, Yong Q Chen¹, Haiqin Chen⁵, Wei Chen⁶

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.
² State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.
³ Teagasc Food Research Centre, Moorepark, Fermoy, Co., Cork, Ireland; APC Microbiome Institute, University College Cork, Cork, Ireland.
⁴ APC Microbiome Institute, University College Cork, Cork, Ireland; College of Science, Engineering and Food Science, University College Cork, Cork, Ireland.
⁵ State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China. Electronic address: haiqinchen@jiangnan.edu.cn.
⁶ State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China. Electronic address: chenwei66@jiangnan.edu.cn.

PMID: 28889933
DOI: 10.1016/j.plipres.2017.09.002

Abstract

Conjugated linoleic acid (CLA) has been shown to exert various potential physiological properties including anti-carcinogenic, anti-obesity, anti-cardiovascular and anti-diabetic activities, and consequently has been considered as a promising food supplement. Bacterial biosynthesis of CLA is an attractive approach for commercial production due to its high isomer-selectivity and convenient purification process. Many bacterial species have been reported to convert free linoleic acid (LA) to CLA, hitherto only the precise CLA-producing mechanisms in Propionibacterium acnes and Lactobacillus plantarum have been illustrated completely, prompting the development of recombinant technology used in CLA production. The purpose of the article is to review the bacterial CLA producers as well as the recent progress on describing the mechanism of microbial CLA-production. Furthermore, the advances and potential in the heterologous expression of CLA genetic determinants will be presented.

Keywords: Bacterial CLA-producers; CLA bioconversion mechanism; Conjugated linoleic acid; Microbial cell factories.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bacteria / cytology
Bacteria / metabolism*
Fungi / cytology
Fungi / metabolism
Humans
Linoleic Acids, Conjugated / biosynthesis*
Linoleic Acids, Conjugated / chemistry

Substances

Linoleic Acids, Conjugated