Neuropeptide Y and its Involvement in Chronic Pain

Neuroscience. 2018 Sep 1:387:162-169. doi: 10.1016/j.neuroscience.2017.08.050. Epub 2017 Sep 7.


Chronic pain is a serious condition that significantly impairs the quality of life, affecting an estimate of 1.5 billion people worldwide. Despite the physiological, emotional and financial burden of chronic pain, there is still a lack of efficient treatments. Neuropeptide Y (NPY) is a highly conserved endogenous peptide in the central and peripheral nervous systems of all mammals, which has been implicated in both pro- and antinociceptive effects. NPY is expressed in the superficial laminae of the dorsal horn of the spinal cord, where it appears to mediate its antinociceptive actions via the Y1 and Y2 receptors. Intrathecal administration of NPY in animal models of neuropathic, inflammatory or postoperative pain has been shown to cause analgesia, even though its exact mechanisms are still unclear. It remains to be seen whether these promising central antinociceptive effects of NPY can be transferred into a future treatment for chronic pain.

Keywords: chronic pain; inflammatory pain; neuropathic pain; neuropeptide Y; spinal cord.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Analgesia
  • Animals
  • Chronic Pain / drug therapy*
  • Chronic Pain / physiopathology*
  • Humans
  • Neuropeptide Y / physiology*
  • Neuropeptide Y / therapeutic use*
  • Receptors, Neuropeptide Y / physiology*


  • Neuropeptide Y
  • Receptors, Neuropeptide Y